Weddle suffered a head laceration and is under an evaluation for a concussion, the team announced.
Weddle was attempting to tackle Panthers running back Christian McCaffrey before McCaffrey hurdled Weddle and Weddle took a knee to the head.
He finished with two tackles.
A 13-year pro, Weddle signed a two-year, $10.5 million deal with the Rams in free agency after he was released by the Baltimore Ravens.
The 34-year-old Weddle has quickly ingrained himself in the Rams’ defense. He took over from linebacker Cory Littleton as the defensive signal caller and was named a team captain.